Publications



26/04/2017 - Photovoltaic restoration of sight in rodents with retinal degeneration

Photovoltaic restoration of sight in rodents with retinal degeneration (Conference Presentation)
Daniel V. Palanker Stanford Univ. (United States)
Proc. SPIE 10052, Optogenetics and Optical Manipulation, 100520I (April 19, 2017); doi:10.1117/12.2250427; http://dx.doi.org/10.1117/12.2250427

07/04/2017 - Deafferented adult rod bipolar cells create new synapses with photoreceptors to restore vision

Loss of photoreceptors during retinal degeneration results in permanent visual impairment. Strategies for vision restoration based on the reintroduction of photoreceptors inherently rely on the ability of the remaining retinal neurons to correctly synapse with new photoreceptors. We show that deafferented bipolar cells in the adult mammalian retina can reconnect to rods and cones and restore retinal sensitivity at scotopic and photopic luminances.
Corinne Beier, Anahit Hovhannisyan, Sydney Weiser, Jennifer Kung, Seungjun Lee, Dae Yeong Lee, Philip Huie, Roopa Dalal, Daniel Palanker and Alexander Sher
Journal of Neuroscience 3 April 2017, 2570-16; DOI: https://doi.org/10.1523/JNEUROSCI.2570-16.2017

25/11/2016 - ARTIFICIAL VISION : Pixium Vision: First Clinical Results and Innovative Developments

Pixium Vision and its partners are developing two VRS solutions for blind patients: an epi-retinal and a sub-retinal approach. This chapter describes the specificities of the epi-retinal IRIS® VRS that has obtained the European CE mark cerfication, and also discuss the associatedinnovations developed at the Vision Institute for future VRS models.

31/08/2016 - ATIS - Event-Based Tone Mapping for Asynchronous Time-Based Image Sensor

The asynchronous time-based neuromorphic image sensor ATIS is an array of autonomously operating pixels able to encode luminance information with an exceptionally high dynamic range (>143 dB). This paper introduces an event-based methodology to display data from this type of event-based imagers, taking into account the large dynamic range and high temporal accuracy that go beyond available mainstream display technologies.
Camille Simon Chane, Sio-Hoi Ieng, Christoph Posch and Ryad B. Benosman
Front. Neurosci., 31 August 2016 | https://doi.org/10.3389/fnins.2016.00391

21/06/2016 - SiC protective coating for photovoltaic retinal prosthesis

SiC coatings demonstrating no erosion in accelerated aging test for 112 d at 87 °C, equivalent to about 10 years in vivo, can offer effective protection of the implants. Photovoltaic retinal prostheses with plasma-enhanced, chemically vapor deposited (PECVD) amorphous silicon carbide (SiC:H) SiC coatings exhibited effective protection from erosion during the 4 month follow-up in vivo.
Xin Lei, Sheryl Kane, Stuart Cogan, Henri Lorach, Ludwig Galambos, Philip Huie, Keith Mathieson, Theodore Kamins, James Harris and Daniel Palanker
Published 21 June 2016 • © 2016 IOP Publishing LtdJournal of Neural Engineering, Volume 13, Number 4

01/06/2016 - Optimization of return electrodes in neurostimulating arrays

Arrays with local return electrodes exhibit improved field confinement and can elicit stronger network-mediated retinal response compared to those with a common remote return. Accurate modeling of multielectrode arrays helps optimize the electrode configuration to maximize the spatial resolution, contrast and dynamic range of retinal prostheses.
Thomas Flores, Georges Goetz, Xin Lei and Daniel Palanker
Published 21 April 2016 • © IOP Publishing Ltd Journal of Neural Engineering, Volume 13, Number 3

13/02/2016 - Implantation of Modular Photovoltaic Subretinal Prosthesis : OSLI Retina Journal

Establish the surgical procedure for subretinal implantation of multiple photovoltaic arrays for the restoration of sight. Multiple silicon photovoltaic arrays of 1 mm in diameter and 30 µm in thickness were implanted subretinally via single retinotomy in rabbits.
Dae Yeong Lee, MD; Henri Lorach, PhD; Phil Huie, MSc; Daniel Palanker, PhD
Ophthalmic Surgery, Lasers and Imaging Retina February 2016 - Volume 47 · Issue 2: 171-174 DOI: 10.3928/23258160-20160126-11

04/12/2015 - Retinal safety of near infrared radiation in photovoltaic restoration of sight

Photovoltaic restoration of sight requires intense near-infrared light to effectively stimulate retinal neurons. We assess the retinal safety of such radiation with and without the retinal implant.
H. Lorach, J. Wang, D. Y. Lee, R. Dalal, P. Huie, and D. Palanker
1 Jan 2016 | Vol. 7, No. 1 | DOI:10.1364/BOE.7.000013 | BIOMEDICAL OPTICS EXPRESS

02/12/2015 - PRIMA - Interactions of Prosthetic and Natural Vision in Animals With Local Retinal Degeneration

Prosthetic restoration of partial sensory loss leads to interactions between artificial and natural inputs. Ideally, the rehabilitation should allow perceptual fusion of the two modalities. Here we studied the interactions between normal and prosthetic vision in a rodent model of local retinal degeneration.
Henri Lorach; Xin Lei; Ludwig Galambos; Theodore Kamins; Keith Mathieson; Roopa Dalal; Philip Huie; James Harris; Daniel Palanker
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7444-7450. doi:10.1167/iovs.15-17521

27/04/2015 - ATIS - Retinomorphic Event-Based Vision Sensors: Bioinspired Cameras With Spiking Output

Retinomorphic Event-Based Vision Sensors: Bioinspired Cameras With Spiking Output
Posch, C.; Serrano-Gotarredona, T.; Linares-Barranco, B.; Delbruck, T.
Proceedings of the IEEE , vol.102, no.10, pp.1470,1484, Oct. 2014

27/04/2015 - Photovoltaic restoration of sight with high visual acuity

PRIMA - Photovoltaic restoration of sight with high visual acuity :
Henri Lorach, Georges Goetz, Richard Smith, Xin Lei, Yossi Mandel, Theodore Kamins, Keith Mathieson, Philip Huie, James Harris, Alexander Sher & Daniel Palanker.
Nature Medicine (2015) doi:10.1038/nm.3851

13/04/2015 - Functional connectivity of visual cortex in the blind follows retinotopic organization principles - BRAIN

Functional connectivity of visual cortex in the blind follows retinotopic organization principles.
E. Striem-Amit et al. BRAIN A journal of Neurology doi:10.1093/brain/awv083 BRAIN 2015: 138; 1679-1695

27/01/2015 - PRIMA - Photovoltaic Pixels for Neural Stimulation: Circuit Models and Performance

Photovoltaic Pixels for Neural Stimulation: Circuit Models and Performance:
D. Boinagrov, X. Lei, G. Goetz, T.I. Kamins, K. Mathieson, L. Galambos, J.S. Harris, and D. Palanker.
IEEE Trans. Biomed. Circuits and Systems (2015) [Epub ahead of print]

19/12/2014 - ATIS - Neuromorphic engineering systems and applications. A snapshot of neuromorphic systems engineering

The papers show the results of feasibility studies of new concepts, as well as neuromorphic systems that have been constructed from more established neuromorphic technologies. Five papers exploit neuromorphic dynamic vision sensor (DVS) events that mimic the asynchronous and sparse spikes on biology's optic nerve fiber.
Tobi Delbruck, André van Schaik and Jennifer Hasler; Frontiers in Neuroscience, 19 December 2014 | doi : 10.3389/fnins.2014.00424

01/11/2014 - Early health economic evaluation of the future potential of next generation artificial vision systems for treating blindness in Germany

Early health economic evaluation of the future potential of next generation artificial vision systems for treating blindness in Germany.
Bjoern Schwander - AHEAD GmbH, Agency of Health Economic Assessment and Dissemination, Arndtstr. 19, Loerrach, 79539, Germany
© 2014 Schwander; licensee Springer.

26/09/2014 - PRIMA - Performance of Photovoltaic Arrays in-vivo and Characteristics of Prosthetic Vision in Animals with Retinal Degeneration

Performance of Photovoltaic Arrays in-vivo and Characteristics of Prosthetic Vision in Animals with Retinal Degeneration.
H. Lorach, G. Goetz, Y. Mandel, X. Lei, T. Kamins, K. Mathieson, P. Huie, R. Dalal, J.S. Harris, D. Palanker.
Vision Research2014 [Epub ahead of print]

10/03/2014 - PRIMA - Selectivity of Direct and Network-mediated Stimulation of the Retinal Ganglion Cells with Epi-, Sub- and Intraretinal Electrodes

Selectivity of Direct and Network-mediated Stimulation of the Retinal Ganglion Cells with Epi-, Sub- and Intraretinal Electrodes.
D. Boinagrov, S. Pangratz-Fuehrer, G. Goetz, and D. Palanker.
Journal of Neural Engineering 11: 026008 (11pp) (2014).

07/11/2013 - The economic burden of visual impairment and blindness : a systematic review

The economic burden of visual impairment and blindness : a systematic review.
Köberlein J, Beifus K, Schaffert C, et al.
BMJ Open 2013;3:e003471.doi:10.1136/bmjopen-2013-003471

18/06/2013 - PRIMA - Cortical Responses Elicited by Photovoltaic Subretinal Prostheses Exhibit Similarities to Visually Evoked Potentials

Cortical Responses Elicited by Photovoltaic Subretinal Prostheses Exhibit Similarities to Visually Evoked Potentials.
Y. Mandel, G. Goetz, D. Lavinsky, P. Huie, K. Mathieson, L. Wang, T. Kamins, L. Galambos, R. Manivanh, J. Harris, D. Palanker. 
Nature Communications 4: 1980 (9 pp) (2013) doi:10.1038/ncomms2980

12/11/2012 - Neural stimulation for visual rehabilitation: advances and challenges

Neural stimulation for visual rehabilitation: advances and challenges.
Lorach H, Marre O, Sahel JA, Benosman R, Picaud S.
J Physiol Paris. 2013 Nov;107(5):421-31. doi: 10.1016/j.jphysparis.2012.10.003. Epub 2012 Nov 10.

12/07/2012 - PRIMA - Photovoltaic retinal prosthesis: implant fabrication and performance

Photovoltaic retinal prosthesis: implant fabrication and performance.
L Wang, K Mathieson, T I Kamins, J D Loudin, L Galambos, G Goetz, A Sher, Y Mandel, P Huie, D Lavinsky, J S Harris and D V Palanker. Journal of Neural Engineering 9: 046014 (11pp) (2012)

03/06/2012 - PRIMA - Photovoltaic retinal prosthesis with high pixel density

Photovoltaic retinal prosthesis with high pixel density.
K. Mathieson, J. Loudin, G. Goetz, P. Huie, L. Wang, T. Kamins, L. Galambos, R. Smith, J.S. Harris, A. Sher and D. Palanker
Nature Photonics 6(6): 391-397 (2012) doi:10.1038/nphoton.2012.104

01/02/2012 - IRIS - Acute electrical stimulation of the human retina with an epiretinal electrode array

Acute epiretinal stimulation of the human retina, using a microelectrode array, can elicit visual perceptions in blind patients with retinitis pigmentosa.
Keserü M, Feucht M, Bornfeld N, Laube T, Walter P, Rössler G, Velikay-Parel M, Hornig R, Richard G.
Acta Ophthalmol. 2012 Feb;90(1):e1-8. doi: 10.1111/j.1755-3768.2011.02288.x. Epub 2011 Nov 8.

11/01/2012 - ATIS - Bio-inspired vision Neuromorphic biomimetic engineering

Nature still outperforms the most powerful computers in routine functions involving perception, sensing and actuation like vision, audition, and motion control, and is, most strikingly, orders of magnitude more energy-efficient than its artificial competitors. In this paper, some basics of neuromorphic electronic engineering and its impact on recent developments in optical sensing and artificial vision are presented. It is demonstrated that bio-inspired vision systems have the potential to outperform conventional, frame-based vision acquisition and processing systems in many application fields and to establish new benchmarks in terms of redundancy suppression/data compression, dynamic range, temporal resolution and power effciency to realize advanced functionality like 3D vision, object tracking, motor control, visual feedback loops, etc. in real-time. It is argued that future artificial vision systems must exploit the power of the asynchronous, frame-free, biomimetic approach.
C. Posch Journal of Instrumentation, Volume 7, January 2012 doi : 10.1088/1748-0221/7/01/C01054

01/01/2011 - ATIS - A QVGA 143 dB Dynamic Range Frame-Free PWM Image Sensor With Lossless Pixel-Level Video Compression and Time-Domain CDS

ATIS - A QVGA 143 dB Dynamic Range Frame-Free PWM Image Sensor With Lossless Pixel-Level Video Compression and Time-Domain CDS. Posch, C. ; Dept. of Safety & Security, AIT Austrian Inst. of Technol. GmbH, Vienna, Austria ; Matolin, D. ; Wohlgenannt, R. IEEE Journal of Solid-State Circuits, vol. 46, no. 1, Jan. 2011

01/12/2010 - Delivery of Information and Power to the Implant, Integration of the Electrode Array with the Retina, and Safety of Chronic Stimulation Chapter 7 : Visual Prosthetics

Delivery of Information and Power to the Implant, Integration of the Electrode Array with the Retina, and Safety of Chronic Stimulation. J. Loudin, A. Butterwick, P. Huie, and D. Palanker. , Chapter 7 in VISUAL PROSTHETICS: Physiology, Bioengineering, Rehabilitation. G. Dagnelie (Editor), Springer 2010

01/12/2007 - IRIS - The IMI Retinal Implant System R. Hornig et al. Chapter 6 Artificial Sight

The IMI Retinal Implant System : Ralf Hornig, Thomas Zehnder, Michaela Velikay-Parel, Thomas Laube, Matthias Feucht, Gisbert Richard 
Chapter in Artificial Sight : Basic Research, Biomedical Engineering, and Clinical Advances
Mark S. Humayun, James D. Weiland, Gerald Chader, Elias Greenbaum
New York: Springer; 2007 pp 111-128 DOI:10.1007/978-0-387-49331-2_6

16/03/2005 - IRIS - Development of an epiretinal prosthesis for stimulation of the human retina

Initial results of acute epiretinal stimulation using an epiretinal implant in legally blind patients demonstrate that acute epiretinal stimulation of the human retina is feasible and safe.
M. Feucht, T. Laube, N. Bornfeld, P. Walter, M. Velikay-Parel, R. Hornig, G. Richard
Ophthalmologe (2005) 102: 688. doi:10.1007/s00347-005-1186-6

22/02/2005 - IRIS - A method and technical equipment for an acute human trial to evaluate retinal implant technology

This paper reports on methods and technical equipment to investigate the epiretinal stimulation of the retina in blind human subjects in acute trials. The eventual goal of the work is the development of a chronically implantable retinal prosthesis to restore a useful level of vision to patients who are blind with outer retinal degenerations, specifically retinitis pigmentosa and macular degeneration.
Ralf Hornig, Thomas Laube, Peter Walter, Michaela Velikay-Parel, Norbert Bornfeld, Matthias Feucht, Harun Akguel, Gernot Rössler, Nils Alteheld, Dietmar Lütke Notarp
J Neural Eng. 2005 Mar;2(1):S129-34. Epub 2005 Feb 22 DOI:10.1088/1741-2560/2/1/014