OBJECTIVE: To evaluate feasibility of restoration of central vision in patients with age-related macular degeneration using a wireless photovoltaic subretinal implant. In particular, to assess safety of sub-retinal implantation and quality of prosthetic vision in patients with geographic atrophy. CONCLUSIONS: Wireless chip PRIMA can be safely implanted under the atrophic

By implanting electrodes that transmit visual information to the surviving neurons in a diseased retina, it's possible to bring the eye's dormant neural circuitry back to life. Daniel Palanker and Georges GoetzPhysics Today : 71, 7, 26 (2018); https://doi.org/10.1063/PT.3.3970 Read more »

According to computational model, pillars having a cathodic return electrode above the INL and active anodic ring electrode at the surface of the implant would enable lower stimulation threshold, compared to planar arrays with circumferential return, but suffer from greater cross-talk between the neighboring pixels. Significance. 3D electrodes in subretinal prostheses

Photovoltaic restoration of sight in rodents with retinal degeneration (Conference Presentation)Daniel V. Palanker Stanford Univ. (United States)Proc. SPIE 10052, Optogenetics and Optical Manipulation, 100520I (April 19, 2017); doi:10.1117/12.2250427; http://dx.doi.org/10.1117/12.2250427 Read more »

Loss of photoreceptors during retinal degeneration results in permanent visual impairment. Strategies for vision restoration based on the reintroduction of photoreceptors inherently rely on the ability of the remaining retinal neurons to correctly synapse with new photoreceptors. We show that deafferented bipolar cells in the adult mammalian retina can reconnect

Pixium Vision and its partners are developing two VRS solutions for blind patients: an epi-retinal and a sub-retinal approach. This chapter describes the specificities of the epi-retinal IRIS® VRS that has obtained the European CE mark cerfication, and also discuss the associatedinnovations developed at the Vision Institute for future VRS models.

The asynchronous time-based neuromorphic image sensor ATIS is an array of autonomously operating pixels able to encode luminance information with an exceptionally high dynamic range (>143 dB). This paper introduces an event-based methodology to display data from this type of event-based imagers, taking into account the large dynamic range and

SiC coatings demonstrating no erosion in accelerated aging test for 112 d at 87 °C, equivalent to about 10 years in vivo, can offer effective protection of the implants. Photovoltaic retinal prostheses with plasma-enhanced, chemically vapor deposited (PECVD) amorphous silicon carbide (SiC:H) SiC coatings exhibited effective protection from erosion during

Arrays with local return electrodes exhibit improved field confinement and can elicit stronger network-mediated retinal response compared to those with a common remote return. Accurate modeling of multielectrode arrays helps optimize the electrode configuration to maximize the spatial resolution, contrast and dynamic range of retinal prostheses.Thomas Flores, Georges Goetz, Xin