|Scientific Publications
Scientific Publications2020-04-20T15:03:00+02:00

Scientific Publications

Restoration of sight in geographic atrophy using a photovoltaic subretinal prosthesis

June 28th, 2019|Categories: Publications|

OBJECTIVE: To evaluate feasibility of restoration of central vision in patients with age-related macular degeneration using a wireless photovoltaic subretinal implant. In particular, to assess safety of sub-retinal implantation and quality of prosthetic vision in patients with geographic atrophy. CONCLUSIONS: Wireless chip PRIMA can be safely implanted under the atrophic

Physics Today : Restoring sight with retinal prostheses

July 31st, 2018|Categories: Publications|

By implanting electrodes that transmit visual information to the surviving neurons in a diseased retina, it's possible to bring the eye's dormant neural circuitry back to life. Daniel Palanker and Georges GoetzPhysics Today : 71, 7, 26 (2018); https://doi.org/10.1063/PT.3.3970 Read more »

Optimization of pillar electrodes in subretinal prosthesis for enhanced proximity to target neurons

March 5th, 2018|Categories: Publications|

According to computational model, pillars having a cathodic return electrode above the INL and active anodic ring electrode at the surface of the implant would enable lower stimulation threshold, compared to planar arrays with circumferential return, but suffer from greater cross-talk between the neighboring pixels. Significance. 3D electrodes in subretinal prostheses

Deafferented adult rod bipolar cells create new synapses with photoreceptors to restore vision

April 7th, 2017|Categories: Publications|

Loss of photoreceptors during retinal degeneration results in permanent visual impairment. Strategies for vision restoration based on the reintroduction of photoreceptors inherently rely on the ability of the remaining retinal neurons to correctly synapse with new photoreceptors. We show that deafferented bipolar cells in the adult mammalian retina can reconnect

ARTIFICIAL VISION : Pixium Vision: First Clinical Results and Innovative Developments

November 25th, 2016|Categories: Publications|

Pixium Vision and its partners are developing two VRS solutions for blind patients: an epi-retinal and a sub-retinal approach. This chapter describes the specificities of the epi-retinal IRIS® VRS that has obtained the European CE mark cerfication, and also discuss the associatedinnovations developed at the Vision Institute for future VRS models.

ATIS – Event-Based Tone Mapping for Asynchronous Time-Based Image Sensor

August 31st, 2016|Categories: Publications|

The asynchronous time-based neuromorphic image sensor ATIS is an array of autonomously operating pixels able to encode luminance information with an exceptionally high dynamic range (>143 dB). This paper introduces an event-based methodology to display data from this type of event-based imagers, taking into account the large dynamic range and

SiC protective coating for photovoltaic retinal prosthesis

June 21st, 2016|Categories: Publications|

SiC coatings demonstrating no erosion in accelerated aging test for 112 d at 87 °C, equivalent to about 10 years in vivo, can offer effective protection of the implants. Photovoltaic retinal prostheses with plasma-enhanced, chemically vapor deposited (PECVD) amorphous silicon carbide (SiC:H) SiC coatings exhibited effective protection from erosion during

Optimization of return electrodes in neurostimulating arrays

June 1st, 2016|Categories: Publications|

Arrays with local return electrodes exhibit improved field confinement and can elicit stronger network-mediated retinal response compared to those with a common remote return. Accurate modeling of multielectrode arrays helps optimize the electrode configuration to maximize the spatial resolution, contrast and dynamic range of retinal prostheses.Thomas Flores, Georges Goetz, Xin

Implantation of Modular Photovoltaic Subretinal Prosthesis : OSLI Retina Journal

February 13th, 2016|Categories: Publications|

Establish the surgical procedure for subretinal implantation of multiple photovoltaic arrays for the restoration of sight. Multiple silicon photovoltaic arrays of 1 mm in diameter and 30 µm in thickness were implanted subretinally via single retinotomy in rabbits.Dae Yeong Lee, MD; Henri Lorach, PhD; Phil Huie, MSc; Daniel Palanker, PhDOphthalmic

PRIMA – Interactions of Prosthetic and Natural Vision in Animals With Local Retinal Degeneration

December 2nd, 2015|Categories: Publications|

Prosthetic restoration of partial sensory loss leads to interactions between artificial and natural inputs. Ideally, the rehabilitation should allow perceptual fusion of the two modalities. Here we studied the interactions between normal and prosthetic vision in a rodent model of local retinal degeneration.Henri Lorach; Xin Lei; Ludwig Galambos; Theodore Kamins;